PCSS-MOUD clinical experts Michelle Lofwall, MD, Larissa Mooney, MD, and Kenneth Morford, MD, who have extensive training and knowledge in addictions, led a team of multidisciplinary professionals in a substantial overhaul of the Substance Use Disorder 101 Core Curriculum for Healthcare Professionals. With the addition of two new module topics, the 23 modules in this 2023 curriculum provide an overview of evidence-based practices in the prevention, identification, and treatment of substance use disorders and co-occurring medical and psychiatric conditions for a variety of populations. Healthcare professionals who complete this curriculum should see an increase in their competence and confidence as they treat patients who are diagnosed with a substance use disorder.